Issue 11, 2013

Bionanomaterials for bone tumor engineering and tumor destruction

Abstract

Recent advances have led to the development of multifunctional bionanomaterials that can target a bone tumor and deliver therapeutic drugs or genes. Bionanomaterial-based bone cancer treatment offers hope for treating bone cancer and provides many exciting possibilities to enable important new therapeutic outcomes. Physicists, chemists, engineers, biologists, and clinicians will continue to address research questions at the level of fundamental biology and science to develop novel biomaterials and systems, particularly enabling cost-effective and large-scale production of multifunctional nanomaterial systems. This review provides a comprehensive reflection of the recent advancements in bionanomaterials for use in bone cancer treatment. The review examines in detail different bionanomaterials (hydroxyapatite nanocrystals and nanometals, nanoscale conjugated copolymer, selenium and liposome) that have been researched and developed over the last six years for bone tissue engineering. It also discusses an important area of research – the use of engineered bone scaffolds in cancer treatment. Recently, bone scaffolds have been identified as potential targets for metastatic spread as well as a means by which escape from tumor dormancy can be studied. This review also includes discussions of a highly potent new class of anticancer compounds, e.g., geminal bisphosphonates, that has been shown to have strong affinity towards various hydroxyapatite-based bone scaffolds with controlled adsorption and release for anticancer activity. Finally, perspectives on future directions in nanotechnology-enabled bone tumor treatment are presented.

Graphical abstract: Bionanomaterials for bone tumor engineering and tumor destruction

Article information

Article type
Feature Article
Submitted
07 Sep 2012
Accepted
14 Jan 2013
First published
16 Jan 2013

J. Mater. Chem. B, 2013,1, 1519-1534

Bionanomaterials for bone tumor engineering and tumor destruction

G. Blackburn, T. G. Scott, I. S. Bayer, A. Ghosh, A. S. Biris and A. Biswas, J. Mater. Chem. B, 2013, 1, 1519 DOI: 10.1039/C3TB00536D

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