Issue 10, 2013
From the journal:

Lab on a Chip

Multiplexed ionic current sensing with glass nanopores†

Nicholas A. W. Bell,a   Vivek V. Thacker,a   Silvia Hernández-Ainsa,a   Maria E. Fuentes-Perez,b   Fernando Moreno-Herrero,b   Tim Liedlc  and  Ulrich F. Keyser*a  

* Corresponding authors

a Cavendish Laboratory, J J Thomson Avenue, Cambridge, United Kingdom
E-mail: ufk20@cam.ac.uk
Fax: +44 (0)1223 337000
Tel: +44 (0)1223 337272

b Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain

c Center for NanoScience and Department of Physics, Ludwig-Maximilians-Universität München, Geschwister-Scholl-Platz 1, 80539 München, Germany

Abstract

We report a method for simultaneous ionic current measurements of single molecules across up to 16 solid state nanopore channels. Each device, costing less than $20, contains 16 glass nanopores made by laser assisted capillary pulling. We demonstrate simultaneous multichannel detection of double stranded DNA and trapping of DNA origami nanostructures to form hybrid nanopores.

Graphical abstract: Multiplexed ionic current sensing with glass nanopores

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Article information

DOI
https://doi.org/10.1039/C3LC50069A
Article type
Technical Innovation
Submitted
14 Jan 2013
Accepted
12 Mar 2013
First published
12 Mar 2013

Lab Chip, 2013,13, 1859-1862

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Multiplexed ionic current sensing with glass nanopores

N. A. W. Bell, V. V. Thacker, S. Hernández-Ainsa, M. E. Fuentes-Perez, F. Moreno-Herrero, T. Liedl and U. F. Keyser, Lab Chip, 2013, 13, 1859 DOI: 10.1039/C3LC50069A

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