Issue 56, 2014
From the journal:

Chemical Communications

The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells†

Qinqin Cheng,‡a   Hongdong Shi,‡a   Hongxia Wang,b   Yuanzeng Min,a   Jun Wang*b  and  Yangzhong Liu*a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn

b School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, China
E-mail: jwang699@ustc.edu.cn

Abstract

Asplatin, a fusion of aspirin and cisplatin, exhibits significant cytotoxicity in tumor cells and almost fully overcomes the drug resistance of cisplatin resistant cells. Asplatin is highly accumulated in cancer cells and is activated upon the reduction by ascorbic acid.

Graphical abstract: The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

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Article information

DOI
https://doi.org/10.1039/C4CC00419A
Article type
Communication
Submitted
17 Jan 2014
Accepted
27 Feb 2014
First published
28 Feb 2014

Chem. Commun., 2014,50, 7427-7430

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The ligation of aspirin to cisplatin demonstrates significant synergistic effects on tumor cells

Q. Cheng, H. Shi, H. Wang, Y. Min, J. Wang and Y. Liu, Chem. Commun., 2014, 50, 7427 DOI: 10.1039/C4CC00419A

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