Issue 86, 2014

Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)

Abstract

Here we present a novel hyperpolarization method, Chemical Reaction-Induced Multi-molecular Polarization (CRIMP), which could be applied to the study of several in vivo processes simultaneously including glycolysis, TCA cycle, fatty acid synthesis and pH mapping. Through the use of non-enzymatic decarboxylation, we generate four hyperpolarized imaging agents from hyperpolarized 1,2-13C pyruvic acid.

Graphical abstract: Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)

Supplementary files

Article information

Article type
Communication
Submitted
08 Aug 2014
Accepted
02 Sep 2014
First published
02 Sep 2014

Chem. Commun., 2014,50, 13030-13033

Author version available

Chemical Reaction-Induced Multi-molecular Polarization (CRIMP)

Y. Lee, N. M. Zacharias, D. Piwnica-Worms and P. K. Bhattacharya, Chem. Commun., 2014, 50, 13030 DOI: 10.1039/C4CC06199C

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