Issue 13, 2014

Macro-/micro-environment-sensitive chemosensing and biological imaging

Abstract

Environment-related parameters, including viscosity, polarity, temperature, hypoxia, and pH, play pivotal roles in controlling the physical or chemical behaviors of local molecules. In particular, in a biological environment, such factors predominantly determine the biological properties of the local environment or reflect corresponding status alterations. Abnormal changes in these factors would cause cellular malfunction or become a hallmark of the occurrence of severe diseases. Therefore, in recent years, they have increasingly attracted research interest from the fields of chemistry and biological chemistry. With the emergence of fluorescence sensing and imaging technology, several fluorescent chemosensors have been designed to respond to such parameters and to further map their distributions and variations in vitro/in vivo. In this work, we have reviewed a number of various environment-responsive chemosensors related to fluorescent recognition of viscosity, polarity, temperature, hypoxia, and pH that have been reported thus far.

Graphical abstract: Macro-/micro-environment-sensitive chemosensing and biological imaging

Article information

Article type
Review Article
Submitted
29 Jan 2014
First published
10 Apr 2014

Chem. Soc. Rev., 2014,43, 4563-4601

Author version available

Macro-/micro-environment-sensitive chemosensing and biological imaging

Z. Yang, J. Cao, Y. He, J. H. Yang, T. Kim, X. Peng and J. S. Kim, Chem. Soc. Rev., 2014, 43, 4563 DOI: 10.1039/C4CS00051J

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