Issue 6, 2014

Polyethylene glycol (PEG) as a reusable solvent medium for an asymmetric organocatalytic Michael addition. Application to the synthesis of bioactive compounds

Abstract

A highly stereoselective organocatalytic Michael addition of aldehydes to trans-β-nitrostyrenes using PEG as a recyclable solvent medium is presented. The scope of this organocatalytic system is demonstrated by the formation of several Michael adducts in good yields and stereoselectivities. Furthermore, applying this new protocol to acetaldehyde, we have disclosed an easy formal synthesis of (R)-pregabalin, (R)-phenibut and (R)-bacoflen with good yields and outstanding enantioselectivities.

Graphical abstract: Polyethylene glycol (PEG) as a reusable solvent medium for an asymmetric organocatalytic Michael addition. Application to the synthesis of bioactive compounds

Supplementary files

Article information

Article type
Paper
Submitted
20 Jan 2014
Accepted
25 Mar 2014
First published
27 Mar 2014

Green Chem., 2014,16, 3169-3174

Author version available

Polyethylene glycol (PEG) as a reusable solvent medium for an asymmetric organocatalytic Michael addition. Application to the synthesis of bioactive compounds

K. S. Feu, A. F. de la Torre, S. Silva, M. A. F. de Moraes Junior, A. G. Corrêa and M. W. Paixão, Green Chem., 2014, 16, 3169 DOI: 10.1039/C4GC00098F

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