Issue 11, 2014

Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms

Abstract

Transcription factors play a key role in the development of a disease. ChIP-sequencing has become a preferred technique to investigate genome-wide binding patterns of transcription factors in vivo. Although this technology has led to many important discoveries, the rapidly increasing number of publicly available ChIP-sequencing datasets still remains a largely unexplored resource. Using a compendium of 144 publicly available murine ChIP-sequencing datasets in blood, we show that systematic bioinformatic analysis can unravel diverse aspects of transcription regulation; from genome-wide binding preferences, finding regulatory partners and assembling regulatory complexes, to identifying novel functions of transcription factors and investigating transcription dynamics during development.

Graphical abstract: Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms

Supplementary files

Article information

Article type
Paper
Submitted
16 Jun 2014
Accepted
08 Aug 2014
First published
11 Aug 2014
This article is Open Access
Creative Commons BY license

Mol. BioSyst., 2014,10, 2935-2941

Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms

A. Joshi and B. Gottgens, Mol. BioSyst., 2014, 10, 2935 DOI: 10.1039/C4MB00354C

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