Issue 12, 2014

Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

Abstract

Promoting clearance of intracellular excessive tau is a potential therapeutic strategy for treating Alzheimer's disease. In this work, we designed and synthesized a cyclen-hybrid artificial ‘hydrolase’ I1-Cu(II) to cleave tau in vitro. Furthermore, a cell-permeable ‘hydrolase’ I2-Cu(II), derived from I1-Cu(II), was also synthesized to cleave intracellular tau proteins.

Graphical abstract: Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

Supplementary files

Article information

Article type
Communication
Submitted
24 Aug 2014
Accepted
26 Sep 2014
First published
26 Sep 2014

Mol. BioSyst., 2014,10, 3081-3085

Clearance of the intracellular high level of the Tau protein directed by an artificial synthetic hydrolase

T. Chu, Q. Li, T. Qiu, Z. Sun, Z. Hu, Y. Chen, Y. Zhao and Y. Li, Mol. BioSyst., 2014, 10, 3081 DOI: 10.1039/C4MB00508B

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