Experimental and theoretical methods for the analyses of dynamic combinatorial libraries

Abstract

Because of their recent interest towards dynamic combinatorial systems, chemists have to challenge their capacity to analyse complex mixtures of components exchanging their molecular fragments over time. Here we present, by a selection of practical examples from the literature, how chromatographic, spectroscopic, and microscopic techniques, as well as theoretical modelling and statistical data treatment, are instrumental in this new research area which is of significance at the interfaces with molecular biology and materials science.