Issue 14, 2014

Messenger RNA (mRNA) nanoparticle tumour vaccination

Abstract

Use of mRNA-based vaccines for tumour immunotherapy has gained increasing attention in recent years. A growing number of studies applying nanomedicine concepts to mRNA tumour vaccination show that the mRNA delivered in nanoparticle format can generate a more robust immune response. Advances in the past decade have deepened our understanding of gene delivery barriers, mRNA's biological stability and immunological properties, and support the notion for engineering innovations tailored towards a more efficient mRNA nanoparticle vaccine delivery system. In this review we will first examine the suitability of mRNA for engineering manipulations, followed by discussion of a model framework that highlights the barriers to a robust anti-tumour immunity mediated by mRNA encapsulated in nanoparticles. Finally, by consolidating existing literature on mRNA nanoparticle tumour vaccination within the context of this framework, we aim to identify bottlenecks that can be addressed by future nanoengineering research.

Graphical abstract: Messenger RNA (mRNA) nanoparticle tumour vaccination

Article information

Article type
Review Article
Submitted
11 Mar 2014
Accepted
24 Apr 2014
First published
05 May 2014

Nanoscale, 2014,6, 7715-7729

Author version available

Messenger RNA (mRNA) nanoparticle tumour vaccination

K. K. L. Phua, S. K. Nair and K. W. Leong, Nanoscale, 2014, 6, 7715 DOI: 10.1039/C4NR01346H

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