Issue 3, 2015
From the journal:

Organic & Biomolecular Chemistry

Short and efficient synthesis of fluorinated δ-lactams†

Thomas J. Cogswell,a   Craig S. Donald,b   De-Liang Long‡a  and  Rodolfo Marquez§*a  

* Corresponding authors

a School of Chemistry, University of Glasgow, Glasgow, UK
E-mail: rudi.marquez@glasgow.ac.uk
Fax: +44 (0)141 330 4888
Tel: +44 (0)141 330 5953

b Oncology iMed, AstraZeneca, Alderley Park, Macclesfield, Cheshire, UK

Abstract

The diastereoselective synthesis of fluorinated δ-lactams has been achieved through an efficient five step process. The route can tolerate a range of functionalities, and provides a quick route for the generation of new fluorinated medicinal building blocks.

Graphical abstract: Short and efficient synthesis of fluorinated δ-lactams

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Article information

DOI
https://doi.org/10.1039/C4OB01547A
Article type
Paper
Submitted
23 Jul 2014
Accepted
29 Aug 2014
First published
29 Aug 2014
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2015,13, 717-728

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Short and efficient synthesis of fluorinated δ-lactams

T. J. Cogswell, C. S. Donald, D. Long and R. Marquez, Org. Biomol. Chem., 2015, 13, 717 DOI: 10.1039/C4OB01547A

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