Issue 47, 2014
From the journal:

Organic & Biomolecular Chemistry

An efficient reagent for covalent introduction of alkynes into proteins†

Jie Zhang,‡ab   Dejun Ma,‡cd   Dawei Du,ab   Zhen Xi*cd  and  Long Yi*abd  

* Corresponding authors

a State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Beijing 100029, Chaoyang District, China
E-mail: yilong@mail.buct.edu.cn

b Public Hatching Platform for Recruited Talents of Beijing University of Chemical Technology, Beijing, China

c State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, National Pesticide Engineering Research Center (Tianjin), Nankai University, Tianjin, China
E-mail: zhenxi@nankai.edu.cn
Tel: +86 22 23504782

d Collaborative Innovation Center of Chemical Science and Engineering, Tianjin, China

Abstract

A cheap and bench-stable reagent was synthesized for direct and covalent introduction of alkynes into tyrosine of target proteins, which can be further modified based on click reaction to achieve fluorescence labelling or PEGylation. This reagent should be a generally useful toolbox for chemical biology and biomaterials.

Graphical abstract: An efficient reagent for covalent introduction of alkynes into proteins

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Article information

DOI
https://doi.org/10.1039/C4OB01873G
Article type
Communication
Submitted
02 Sep 2014
Accepted
15 Oct 2014
First published
16 Oct 2014

Org. Biomol. Chem., 2014,12, 9528-9531

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An efficient reagent for covalent introduction of alkynes into proteins

J. Zhang, D. Ma, D. Du, Z. Xi and L. Yi, Org. Biomol. Chem., 2014, 12, 9528 DOI: 10.1039/C4OB01873G

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