Issue 3, 2015

Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release

Abstract

Delicate mesoscopic architectures, bearing complex forms with multiple hierarchy levels, lead to significant functions in biogenic minerals. Herein, a bio-inspired approach was developed to fabricate comet-shaped assemblies of an anti-tumor drug – 10-hydroxycamptothecin (HCPT). The anti-solvent co-precipitation of HCPT and the excipient – PEG-b-PLGA – within the emulsifier leads to the immediate nucleation of comet bundles, followed by a secondary nucleation to generate the comet head, which is an assembly of nanofibers aligned almost in parallel. The continuous manufacturing furnishes drug–excipient hybrid particles with high drug-loading and a sustained drug release profile. This simple and efficient bio-inspired approach led to a promising sustained local drug delivery system, and could be extended to the fabrication of other functional organic materials bearing mesoscopic structural units.

Graphical abstract: Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release

Supplementary files

Article information

Article type
Edge Article
Submitted
05 Nov 2014
Accepted
28 Dec 2014
First published
06 Jan 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 1650-1654

Author version available

Integration of an anti-tumor drug into nanocrystalline assemblies for sustained drug release

X. Yang, S. Wu, Y. Li, Y. Huang, J. Lin, D. Chang, S. Ye, L. Xie, Y. Jiang and Z. Hou, Chem. Sci., 2015, 6, 1650 DOI: 10.1039/C4SC03392B

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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