Issue 58, 2015
From the journal:

Chemical Communications

Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile†

Emerson Rodrigo da Silva,*ab   Wendel Andrade Alves,a   Valeria Castelletto,b   Mehedi Reza,c   Janne Ruokolainen,c   Rohanah Hussaind  and  Ian William Hamley*b  

* Corresponding authors

a Centro de Ciéncias Naturais e Humanas, Universidade Federal do ABC, Santo André 09210-580, Brazil
E-mail: ersilva@ufabc.edu.br

b Department of Chemistry, University of Reading, Whiteknights Reading, Berkshire RG6 6AD, UK
E-mail: i.w.hamley@reading.ac.uk

c Department of Applied Physics, Aalto University School of Science, P. O. Box 15100, FI-00076, Finland

d Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK

Abstract

The self-assembly of peptide nanotubes formed by an L-glutamic acid-based bolaamphiphile is shown to proceed via a remarkable mechanism where the peptide conformation changes from β-sheet to unordered. The kinetics of this process are elucidated via X-ray scattering and UV circular dichroism methods. The reverse transition from “unordered” to β-sheet structures is triggered by UV radiation.

Graphical abstract: Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile

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Article information

DOI
https://doi.org/10.1039/C5CC03640B
Article type
Communication
Submitted
01 May 2015
Accepted
14 Jun 2015
First published
15 Jun 2015

Chem. Commun., 2015,51, 11634-11637

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Self-assembly pathway of peptide nanotubes formed by a glutamatic acid-based bolaamphiphile

E. R. da Silva, W. A. Alves, V. Castelletto, M. Reza, J. Ruokolainen, R. Hussain and I. W. Hamley, Chem. Commun., 2015, 51, 11634 DOI: 10.1039/C5CC03640B

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