Phosphovanadomolybdic acid catalyzed desulfurization–oxygenation of secondary and tertiary thioamides into amides using molecular oxygen as the terminal oxidant

Abstract

In the presence of phosphovanadomolybdic acids, e.g., H₆PV₃Mo₉O₄₀, desulfurization–oxygenation of various kinds of structurally diverse secondary and tertiary thioamides proceeded efficiently using molecular oxygen as the terminal oxidant, affording the corresponding amides in moderate to excellent yields. In addition, ¹⁸O-labeled amides could readily be synthesized using H₂¹⁸O as the oxygen source.