Issue 1, 2016

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

Abstract

A versatile multistep continuous flow setup is reported for the four-step conversion of anilines into pyrazole products. The synthesis machine incorporates the use of amine-redox chemistry through diazotization and a metal-free vitamin C mediated reduction. The machine can be used for the synthesis of an array of analogues or the scale up of an individual target.

Graphical abstract: A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

Supplementary files

Article information

Article type
Paper
Submitted
23 Nov 2015
Accepted
23 Dec 2015
First published
07 Jan 2016
This article is Open Access
Creative Commons BY license

React. Chem. Eng., 2016,1, 101-105

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process

J. Poh, D. L. Browne and S. V. Ley, React. Chem. Eng., 2016, 1, 101 DOI: 10.1039/C5RE00082C

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