Issue 3, 2016

Design and functionalization of responsive hydrogels for photonic crystal biosensors

Abstract

Photonic crystals embedded in analyte responsive hydrogels provide a powerful platform for biosensing and have benefitted from recent advances in polymer synthesis and functionalization, nanofabrication, and optical characterization. In this review, state-of-the-art techniques for the fabrication and functionalization of photonic crystal hydrogels are presented, along with a fundamental description of how such materials transduce detection of a target analyte into a simple optical readout. Specific biosensing applications using photonic crystal hydrogels are highlighted, including for the detection of DNA hybridization and single-site DNA modifications, enzyme activity, and small molecule metabolites. Moreover, perspectives on using molecular-level interactions to design and engineer more sensitive or more selective biosensors, as well as future directions in this expanding field, are discussed.

Graphical abstract: Design and functionalization of responsive hydrogels for photonic crystal biosensors

Article information

Article type
Review Article
Submitted
31 Mar 2016
Accepted
25 Apr 2016
First published
10 May 2016

Mol. Syst. Des. Eng., 2016,1, 225-241

Design and functionalization of responsive hydrogels for photonic crystal biosensors

S. Jung, J. L. Kaar and M. P. Stoykovich, Mol. Syst. Des. Eng., 2016, 1, 225 DOI: 10.1039/C6ME00031B

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