Issue 44, 2016
From the journal:

Organic & Biomolecular Chemistry

Total synthesis of (±)-ganocins B and C†

Yao Liu,a   Chu-Jun Zhou,a   Qingjiang Li*ab  and  Honggen Wang*a  

* Corresponding authors

a School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China

b State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China
E-mail: liqingj3@mail.sysu.edu.cn, wanghg3@mail.sysu.edu.cn

Abstract

The first total synthesis of structurally unique polycyclic phenolic meroterpenoids, ganocins B and C is reported. The synthesis features gold-catalyzed intramolecular cascade cyclization to construct the C/D ring bearing an angular methyl group, diastereoselective Michael addition, and acid-mediated one-pot Robinson cyclization/deprotection/isomerization.

Graphical abstract: Total synthesis of (±)-ganocins B and C

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Article information

DOI
https://doi.org/10.1039/C6OB02049F
Article type
Communication
Submitted
19 Sep 2016
Accepted
01 Oct 2016
First published
17 Oct 2016

Org. Biomol. Chem., 2016,14, 10362-10365

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Total synthesis of (±)-ganocins B and C

Y. Liu, C. Zhou, Q. Li and H. Wang, Org. Biomol. Chem., 2016, 14, 10362 DOI: 10.1039/C6OB02049F

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