Issue 15, 2017

Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery

Abstract

An unnatural CDP-amino acid (kd) is used in the design and synthesis of novel cell penetrating peptidomimetic (Kkd-5). The balanced cationic nature and structural rigidity of Kkd-5 resulted in serum stability, non-toxicity to cells, and interaction with membrane and DNA, all of which facilitated efficient cellular uptake and DNA delivery.

Graphical abstract: Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery

Supplementary files

Article information

Article type
Communication
Submitted
21 Jan 2017
Accepted
20 Mar 2017
First published
21 Mar 2017

Org. Biomol. Chem., 2017,15, 3170-3174

Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery

C. Madhu, C. Voshavar, K. Rajasekhar and T. Govindaraju, Org. Biomol. Chem., 2017, 15, 3170 DOI: 10.1039/C7OB00167C

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