Ru(II)-Catalyzed annulation of benzamidines and alkynes by C–H/N–H activation: a facile synthesis of 1-aminoisoquinolines

P. P. Kaishap; G. Duarah; D. Chetia; S. Gogoi

doi:10.1039/C7OB00389G

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Ru(ii)-Catalyzed annulation of benzamidines and alkynes by C–H/N–H activation: a facile synthesis of 1-aminoisoquinolines†

P. P. Kaishap,

^a G. Duarah,^a D. Chetia^b and S. Gogoi

*^a

Author affiliations

* Corresponding authors

^a Applied Organic Chemistry, Chemical Sciences & Technology Division, CSIR-North East Institute of Science and Technology, AcSIR, Jorhat-785006, India
E-mail: skgogoi1@gmail.com
Fax: +913762370011
Tel: +913762372948

^b Department of Pharm. Sciences, Dibrugarh University, Dibrugarh, India

Abstract

An inexpensive Ru(II) complex catalyzes the oxidative annulation reaction of disubstituted alkynes with benzamidines to provide highly valuable 1-aminoisoquinolines in high yields. The reaction also features excellent regioselectivity with some unsymmetrical alkynes.

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Article information

DOI: https://doi.org/10.1039/C7OB00389G
Article type: Paper
Submitted: 16 Feb 2017
Accepted: 03 Apr 2017
First published: 03 Apr 2017

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Org. Biomol. Chem., 2017,15, 3491-3498

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Ru(II)-Catalyzed annulation of benzamidines and alkynes by C–H/N–H activation: a facile synthesis of 1-aminoisoquinolines

P. P. Kaishap, G. Duarah, D. Chetia and S. Gogoi, Org. Biomol. Chem., 2017, 15, 3491 DOI: 10.1039/C7OB00389G

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Organic & Biomolecular Chemistry

Ru(ii)-Catalyzed annulation of benzamidines and alkynes by C–H/N–H activation: a facile synthesis of 1-aminoisoquinolines†

Abstract

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Ru(II)-Catalyzed annulation of benzamidines and alkynes by C–H/N–H activation: a facile synthesis of 1-aminoisoquinolines

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