Issue 20, 2017

FeCl3 catalysed 7-membered ring formation in a single pot: a new route to indole-fused oxepines/azepines and their cytotoxic activity

Abstract

Various oxepine and azepine fused N-heterocyclic derivatives were synthesized using a new and one-pot reaction of 2,3-dichloro quinoxaline/pyrazine with 2-(1H-indol-2-yl)phenol/aniline in the presence of 25 mol% FeCl3. The reaction proceeded via C–C bond followed by C–X (X = O or N) bond formation to construct the central 7-membered ring, affording the desired products in good yields. The structure assignment was confirmed by the single crystal X-ray analysis of a synthesized oxepine fused N-heterocycle derivative. Most of the synthesized compounds were found to be promising when tested for their anti-proliferative properties against cervical and breast cancer cell lines.

Graphical abstract: FeCl3 catalysed 7-membered ring formation in a single pot: a new route to indole-fused oxepines/azepines and their cytotoxic activity

Supplementary files

Article information

Article type
Paper
Submitted
23 Mar 2017
Accepted
04 May 2017
First published
04 May 2017

Org. Biomol. Chem., 2017,15, 4468-4476

FeCl3 catalysed 7-membered ring formation in a single pot: a new route to indole-fused oxepines/azepines and their cytotoxic activity

K. Shiva Kumar, M. Siddi Ramulu, B. Rajesham, N. P. Kumar, V. Voora and R. K. Kancha, Org. Biomol. Chem., 2017, 15, 4468 DOI: 10.1039/C7OB00715A

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