Asymmetric synthesis of CF3-containing tetrahydroquinoline via a thiourea-catalyzed cascade reaction

Abstract

An organocatalytic asymmetric method for the synthesis of 2-CF₃ tetrahydroquinoline has been achieved. The cascade reaction of 2-aminochalcones with β-CF₃ nitroalkenes afforded the products bearing three contiguous stereogenic centers in good yields with excellent diastereoselectivities and enantioselectivities.