Issue 25, 2017

Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions

Abstract

Carpatizine (1), a new bridged oxazine derivative, was isolated from a marine-derived Streptomyces strain SNE-011. The structure was fully determined by spectroscopic analysis, ECD calculations and chemical methods. A plausible non-enzymatic reaction mechanism from daryamide D leading to carpatizine was presented, which was confirmed by chemical transformation.

Graphical abstract: Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions

Supplementary files

Article information

Article type
Communication
Submitted
15 May 2017
Accepted
06 Jun 2017
First published
06 Jun 2017

Org. Biomol. Chem., 2017,15, 5275-5278

Carpatizine, a novel bridged oxazine derivative generated by non-enzymatic reactions

P. Fu and J. B. MacMillan, Org. Biomol. Chem., 2017, 15, 5275 DOI: 10.1039/C7OB01178D

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