A monocyclic “temple” synthetic lectin, with extended electron-rich aromatic surfaces, shows enhanced affinities for carbohydrates in water. The methoxy substituents favour binding to α-linked maltodextrins, against the all-equatorial substrates normally favoured by this family of receptors.
P. Stewart, C. M. Renney, T. J. Mooibroek, S. Ferheen and A. P. Davis, Chem. Commun., 2018, 54, 8649 DOI: 10.1039/C8CC05074K
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