Issue 1, 2021

Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis

Abstract

The synergy of an Ir-based photosensitizer with mild oxidizing ability and a thiol catalyst enables efficient allylic C–H functionalization of enol silyl ethers with imines under visible light irradiation. Subsequent transformations of the aminoalkylated enol silyl ethers allow for the facile construction of unique molecular frameworks such as functionalized octahydroisoindol-4-one.

Graphical abstract: Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis

Supplementary files

Article information

Article type
Communication
Submitted
09 Sep 2020
Accepted
23 Sep 2020
First published
23 Sep 2020

Org. Biomol. Chem., 2021,19, 141-145

Mannich-type allylic C–H functionalization of enol silyl ethers under photoredox–thiol hybrid catalysis

T. Nakashima, K. Ohmatsu and T. Ooi, Org. Biomol. Chem., 2021, 19, 141 DOI: 10.1039/D0OB01862G

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