Issue 13, 2021

A mechanistic investigation of the Suzuki polycondensation reaction using MS/MS methods

Abstract

Understanding catalytic reactions is inherently difficult because not only is the catalyst the least abundant component in the mixture, but it also takes many different forms as the reaction proceeds. Precatalyst is converted into active catalyst, short-lived intermediates, resting states, and decomposition products. Polymerization catalysis is harder yet to study, because as the polymer grows the identities of these species change with every turnover as monomers are added to the chain. Modern mass spectrometric methods have proved to be up to the challenge, with multiple reaction monitoring (MRM) in conjunction with pressurized sample infusion (PSI) used to continuously probe all stages of the Suzuki polycondensation (SPC) reaction. Initiation, propagation, and termination steps were tracked in real time, as well as the side products from undesirable aryl-phosphine scrambling. The outstanding sensitivity and low signal-to-noise of the approach has real promise with respect to the depth with which this reaction and others like it can be studied.

Graphical abstract: A mechanistic investigation of the Suzuki polycondensation reaction using MS/MS methods

Supplementary files

Article information

Article type
Paper
Submitted
27 Apr 2021
Accepted
27 May 2021
First published
28 May 2021

Catal. Sci. Technol., 2021,11, 4406-4416

A mechanistic investigation of the Suzuki polycondensation reaction using MS/MS methods

M. Y. C. Ting, L. P. E. Yunker, I. C. Chagunda, K. Hatlelid, M. Vieweg and J. S. McIndoe, Catal. Sci. Technol., 2021, 11, 4406 DOI: 10.1039/D1CY00743B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements