Issue 22, 2003

Diversity-oriented synthesis; a challenge for synthetic chemists

Abstract

The efficient, simultaneous synthesis of structurally diverse compounds, better known as diversity-oriented synthesis (DOS), is not obvious, and remains a challenge to synthetic chemistry. This personal account details why DOS has such enormous implications for the discovery of small molecules with desired properties, such as catalysts, synthetic reagents, biological probes and new drugs. Also, I describe the evolution behind the current state-of-play of DOS.

Graphical abstract: Diversity-oriented synthesis; a challenge for synthetic chemists

Supplementary files

Article information

Article type
Emerging Area
Submitted
03 Sep 2003
Accepted
24 Sep 2003
First published
13 Oct 2003

Org. Biomol. Chem., 2003,1, 3867-3870

Diversity-oriented synthesis; a challenge for synthetic chemists

D. R. Spring, Org. Biomol. Chem., 2003, 1, 3867 DOI: 10.1039/B310752N

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