Issue 10, 2005

Catalytic asymmetric hydroamination of non-activated olefins

Abstract

Hydroamination is a highly atom-economical process in which an amine N–H functionality is added to an unsaturated carbon–carbon linkage. This potentially highly useful process gives access to various nitrogen-containing basic and fine chemicals as well as naturally occurring alkaloid skeletons. Asymmetric hydroamination reactions promoted by chiral catalysts are particularly attractive. This review highlights recent progress in the development of early transition metal catalysts for the asymmetric hydroamination of non-activated alkenes.

Graphical abstract: Catalytic asymmetric hydroamination of non-activated olefins

Article information

Article type
Emerging Area
Submitted
09 Dec 2004
Accepted
17 Mar 2005
First published
07 Apr 2005

Org. Biomol. Chem., 2005,3, 1819-1824

Catalytic asymmetric hydroamination of non-activated olefins

K. C. Hultzsch, Org. Biomol. Chem., 2005, 3, 1819 DOI: 10.1039/B418521H

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