Issue 24, 2005

Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors

Abstract

Hydrogen-bonding interaction plays a crucial role in the molecular recognition and activation processes of various biologically important reactions that are mediated by enzymes and antibodies in living organisms. Recently, it has been shown that a hydrogen-bonding donor can be used as a general acid catalyst for various types of reactions in organic chemistry. In this article, we describe enantioselective reactions catalyzed by urea and thiourea derivatives as general acid catalysts as well as diastereoselective reactions. This perspective provides an overview of this rapidly growing field.

Graphical abstract: Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors

Article information

Article type
Perspective
Submitted
05 Aug 2005
Accepted
28 Sep 2005
First published
20 Oct 2005

Org. Biomol. Chem., 2005,3, 4299-4306

Recognition and activation by ureas and thioureas: stereoselective reactions using ureas and thioureas as hydrogen-bonding donors

Y. Takemoto, Org. Biomol. Chem., 2005, 3, 4299 DOI: 10.1039/B511216H

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