Issue 11, 2007
From the journal:

Chemical Communications

A rationally designed macrocyclic cavitand that kills bacteria with high efficacy and good selectivity†

Jinny Choi,a   Jeeyeon Kim,b   Kimoon Kim,*b   Sung-Tae Yang,a   Jae-Il Kima  and  Sangyong Jon*a  

* Corresponding authors

a Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, Korea
E-mail: syjon@gist.ac.kr
Fax: +82 62-970-2484
Tel: +82 62-970-2304

b National Creative Research Initiative Center for Smart Supramolecules (CSS) and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Korea
E-mail: kkim@postech.ac.kr
Fax: +82 54-279-8129
Tel: +82 54-279-2113

Abstract

An amphiphilic macrocyclic cavitand that shows good antibacterial activity, comparable to that of peptide-based antibiotics was developed by rational design and its antibacterial selectivity over mammalian cells was examined.

Graphical abstract: A rationally designed macrocyclic cavitand that kills bacteria with high efficacy and good selectivity

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Article information

DOI
https://doi.org/10.1039/B617005F
Article type
Communication
Submitted
22 Nov 2006
Accepted
13 Dec 2006
First published
10 Jan 2007

Chem. Commun., 2007, 1151-1153

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A rationally designed macrocyclic cavitand that kills bacteria with high efficacy and good selectivity

J. Choi, J. Kim, K. Kim, S. Yang, J. Kim and S. Jon, Chem. Commun., 2007, 1151 DOI: 10.1039/B617005F

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