Issue 7, 2007

Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system

Abstract

The direct three-component Mannich reactions of O-benzyl hydroxyacetone with p-anisidine and aromatic or aliphatic aldehydes in the presence of an L-threonine-derived catalyst afforded anti-1,2-amino alcohols in good-to-excellent yields and with enantioselectivities of up to 97%. This study is the first demonstration that direct three-component Mannich reactions can be promoted by a primary amino acid in water.

Graphical abstract: Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system

Supplementary files

Article information

Article type
Communication
Submitted
01 Feb 2007
Accepted
05 Feb 2007
First published
14 Feb 2007

Org. Biomol. Chem., 2007,5, 1018-1020

Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system

L. Cheng, X. Wu and Y. Lu, Org. Biomol. Chem., 2007, 5, 1018 DOI: 10.1039/B701579H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements