Issue 15, 2008
From the journal:

Chemical Communications

Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex†

Johanna Niesel,a   Antonio Pinto,a   Harmel W. Peindy N'Dongo,a   Klaus Merz,a   Ingo Ott,b   Ronald Gustb  and  Ulrich Schatzschneider*a  

* Corresponding authors

a Lehrstuhl für Anorganische Chemie I-Bioanorganische Chemie, Ruhr-Universität Bochum NC 3/74, Universitätsstraße 150, Bochum, Germany
E-mail: ulrich.schatzschneider@rub.de
Fax: +49 (0)234 32 14378
Tel: +49 (0)234 32 24187

b Institut für Pharmazie, Freie Universität Berlin, Königin-Luise-Straße 2+4, Berlin, Germany

Abstract

Cell viability studies of HT29 colon cancer cells treated with the CO-releasing compound [Mn(CO)3(tpm)]PF6 revealed a significant photoinduced cytotoxicity comparable to that of established agent 5-fluorouracil (5-FU), while controls kept in the dark were unaffected at up to 100 µM.

Graphical abstract: Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

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Article information

DOI
https://doi.org/10.1039/B719075A
Article type
Communication
Submitted
11 Dec 2007
Accepted
10 Jan 2008
First published
08 Feb 2008

Chem. Commun., 2008, 1798-1800

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Photoinduced CO release, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex

J. Niesel, A. Pinto, H. W. P. N'Dongo, K. Merz, I. Ott, R. Gust and U. Schatzschneider, Chem. Commun., 2008, 1798 DOI: 10.1039/B719075A

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