Issue 1, 2009
From the journal:

Chemical Communications

Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs†

Kyeng Min Park,a   Kyungwon Suh,a   Hyuntae Jung,b   Don-Wook Lee,b   Youngjoo Ahn,a   Jeeyeon Kim,a   Kangkyun Baeka  and  Kimoon Kim*ab  

* Corresponding authors

a National Creative Research Initiative Center for Smart Supramolecules (CSS) and Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Korea
E-mail: kkim@postech.ac.kr
Fax: +82 54-279-8129
Tel: +82 54-279-2113

b School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea

Abstract

Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.

Graphical abstract: Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs

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Article information

DOI
https://doi.org/10.1039/B815009E
Article type
Communication
Submitted
28 Aug 2008
Accepted
20 Oct 2008
First published
13 Nov 2008

Chem. Commun., 2009, 71-73

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Cucurbituril-based nanoparticles: a new efficient vehicle for targeted intracellular delivery of hydrophobic drugs

K. M. Park, K. Suh, H. Jung, D. Lee, Y. Ahn, J. Kim, K. Baek and K. Kim, Chem. Commun., 2009, 71 DOI: 10.1039/B815009E

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