Issue 11, 2010

Electrochemical DNA sandwich assay with a lipase label for attomole detection ofDNA

Abstract

A fast and sensitive electrochemical lipase-based sandwich hybridization assay for detection of attomole levels of DNA has been developed. A combination of magnetic beads, used for pre-concentration and bioseparation of the analyte with a lipase catalyst label allowed detection ofDNA with a limit of 20 amol.

Graphical abstract: Electrochemical DNA sandwich assay with a lipase label for attomole detection of DNA

Supplementary files

Article information

Article type
Communication
Submitted
24 Nov 2009
Accepted
03 Feb 2010
First published
12 Feb 2010

Chem. Commun., 2010,46, 1836-1838

Electrochemical DNA sandwich assay with a lipase label for attomole detection ofDNA

E. E. Ferapontova, M. N. Hansen, A. M. Saunders, S. Shipovskov, D. S. Sutherland and K. V. Gothelf, Chem. Commun., 2010, 46, 1836 DOI: 10.1039/B924627D

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