Issue 5, 2011
From the journal:

Dalton Transactions

Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties†

Andrew Kellett,*a   Mark O'Connor,a   Malachy McCann,b   Mary McNamara,a   Patrick Lynch,a   Georgina Rosair,c   Vickie McKee,d   Bernie Creaven,e   Maureen Walsh,e   Siobhan McClean,e   Agnieszka Foltyn,e   Denis O'Shea,a   Orla Howea  and  Michael Devereux*a  

* Corresponding authors

a The inorganic pharmaceutical and biomimetic research centre, Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin, Ireland
E-mail: andrew.kellett@dit.ie, michael.devereux@dit.ie
Tel: +353 1 4027986, +353 1 4024680

b Chemistry Department, National University of Ireland, Maynooth, Co. Kildare, Ireland

c School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK

d Department of Chemistry, Loughborough University, Loughborough, Leicestershire, UK

e Centre of Applied Science for Health, Institute of Technology Tallaght Dublin, Tallaght, Dublin, Ireland

Abstract

Three, structurally characterised, bis-phen Cu(II) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A–T)]2 and Poly[d(G–C)]2 binding.

Graphical abstract: Bis-phenanthroline copper(ii) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

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Article information

DOI
https://doi.org/10.1039/C0DT01607A
Article type
Communication
Submitted
18 Nov 2010
Accepted
30 Nov 2010
First published
16 Dec 2010

Dalton Trans., 2011,40, 1024-1027

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Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with ‘self-activating’ metallo-nuclease and DNA binding properties

A. Kellett, M. O'Connor, M. McCann, M. McNamara, P. Lynch, G. Rosair, V. McKee, B. Creaven, M. Walsh, S. McClean, A. Foltyn, D. O'Shea, O. Howe and M. Devereux, Dalton Trans., 2011, 40, 1024 DOI: 10.1039/C0DT01607A

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