Issue 4, 2011
From the journal:

MedChemComm

Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies†‡

Paras N. Yadav,§a   Ramsay E. Beveridge,a   Jonathan Blay,b   Alaina R. Boyd,a   Maja W. Chojnacka,c   Andreas Decken,||d   Ankur A. Deshpande,a   Michael G. Gardiner,**e   Trevor W. Hambley,f   Michael J. Hughes,a   Leslie Jolly,e   Jacquelyn A. Lavangie,a   Timothy D. MacInnis,a   Sherri A. McFarland,*a   Elizabeth J. Newf  and  Robert A. Gossage*ac  

* Corresponding authors

a Department of Chemistry, Acadia University, Wolfville, Canada
E-mail: sherri.mcfarland@acadiau.ca
Fax: +1-902-5851114

b Department of Pharmacology, Sir Charles Tupper Medical Building, Dalhousie University, 5850 College Street, Halifax, Canada

c Ryerson University, Department of Chemistry & Biology, 350 Victoria Street, Toronto, Canada
E-mail: gossage@ryerson.ca
Fax: +1-416-9795044

d Department of Chemistry, University of New Brunswick, Fredericton, Canada

e School of Chemistry, The University of Tasmania, Hobart, Australia

f School of Chemistry, The University of Sydney, Sydney, Australia

Abstract

The syntheses, characterisation and biological activities (IC50; DNA binding) of four mononuclear Pt oxazoline complexes are reported. These materials are the compounds cis-[PtCl2(NH3)(Etox-κ1N)] (1: Etox = 2-ethyl-2-oxazoline), [PtCl2(anilox-κ2N,N′)] (2: anilox = 4,4-dimethyl-2-[o-anilinyl]-2-oxazoline), cis-[PtCl2(Etox-κ1N)2] (3) and [PtCl(pyox-κ3N,N′,N′)] (4: pyoxH = pyridine-2-carboxyanil-[o-{4,4-dimethyl-2-oxazolinyl}-ide]) and all four are shown to have slightly lower cytotoxicities in vitro when compared to cisplatin against the A2780 ovarian cancer cell line. These new materials all appear to be bio-active via the formation of DNA adducts. Complexes 1 and 2 have been further characterised in the solid-state by X-ray diffraction methods.

Graphical abstract: Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

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Article information

DOI
https://doi.org/10.1039/C0MD00211A
Article type
Concise Article
Submitted
10 Nov 2010
Accepted
14 Dec 2010
First published
24 Jan 2011

Med. Chem. Commun., 2011,2, 274-277

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Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies

P. N. Yadav, R. E. Beveridge, J. Blay, A. R. Boyd, M. W. Chojnacka, A. Decken, A. A. Deshpande, M. G. Gardiner, T. W. Hambley, M. J. Hughes, L. Jolly, J. A. Lavangie, T. D. MacInnis, S. A. McFarland, E. J. New and R. A. Gossage, Med. Chem. Commun., 2011, 2, 274 DOI: 10.1039/C0MD00211A

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