Issue 10, 2011

Recent advances in Sonogashira reactions

Abstract

The coupling of aryl or vinyl halides with terminal acetylenes catalysed by palladium and other transition metals, commonly termed as Sonogashira cross-coupling reaction, is one of the most important and widely used sp2–sp carboncarbon bond formation reactions in organic synthesis, frequently employed in the synthesis of natural products, biologically active molecules, heterocycles, molecular electronics, dendrimers and conjugated polymers or nanostructures. This critical review focuses on developments in the Sonogashira reaction achieved in recent years concerning catalysts, reaction conditions and substrates (352 references).

Graphical abstract: Recent advances in Sonogashira reactions

Article information

Article type
Critical Review
Submitted
18 Mar 2011
First published
08 Jun 2011

Chem. Soc. Rev., 2011,40, 5084-5121

Recent advances in Sonogashira reactions

R. Chinchilla and C. Nájera, Chem. Soc. Rev., 2011, 40, 5084 DOI: 10.1039/C1CS15071E

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