Issue 1, 2012
From the journal:

Green Chemistry

Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

Saravanakumar Shanmuganathan,a   Dessy Natalia,a   Lasse Greiner*ab  and  Pablo Domínguez de María*a  

* Corresponding authors

a Institut für Technische und Makromolekulare Chemie (ITMC), RWTH Aachen University, Worringerweg 1, Aachen, Germany
E-mail: dominguez@itmc.rwth-aachen.de
Fax: +49 241 8022177
Tel: +49 241 8020468

b DECHEMA e.V. Karl-Winnacker-Institut, Theodor-Heuss-Allee 25, Frankfurt am Main, Germany
E-mail: greiner@dechema.de
Fax: +49 697564388
Tel: +49 697564337

Abstract

A one-pot multi-step approach comprising enzymatic oxidation-hydroxymethylation-reduction enables the synthesis of optically active α-aryl vicinal diols with high yields and enantioselectivities. Formaldehyde required for the hydroxymethylation step is enzymatically produced in situ using less hazardous methanol as substrate.

Graphical abstract: Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

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Article information

DOI
https://doi.org/10.1039/C1GC16092C
Article type
Communication
Submitted
01 Sep 2011
Accepted
15 Nov 2011
First published
08 Dec 2011

Green Chem., 2012,14, 94-97

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Oxidation-hydroxymethylation-reduction: a one-pot three-step biocatalytic synthesis of optically active α-aryl vicinal diols

S. Shanmuganathan, D. Natalia, L. Greiner and P. Domínguez de María, Green Chem., 2012, 14, 94 DOI: 10.1039/C1GC16092C

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