Issue 5, 2011

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

Abstract

A 4-component antibody–phthalocyanine–polyethylene glycol–gold nanoparticle conjugate is described for use as a potential drug for targeted photodynamic cancer therapy. Gold nanoparticles (4 nm) were stabilised with a self-assembled layer of a zinc–phthalocyanine derivative (photosensitiser) and a heterobifunctional polyethylene glycol. Anti-HER2 monoclonal antibodies were covalently bound to the nanoparticlesvia a terminal carboxy moiety on the polyethylene glycol. The nanoparticle conjugates were stable towards aggregation, and under irradiation with visible red light efficiently produced cytotoxic singlet oxygen. Cellular experiments demonstrated that the nanoparticle conjugates selectively target breast cancer cells that overexpress the HER2 epidermal growth factor cell surface receptor, and that they are effective photodynamic therapy agents.

Graphical abstract: Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyanine–gold nanoparticle conjugates

Article information

Article type
Paper
Submitted
11 Jan 2011
Accepted
07 Mar 2011
First published
01 Apr 2011

Photochem. Photobiol. Sci., 2011,10, 822-831

Targeted photodynamic therapy of breast cancer cells using antibody–phthalocyaninegold nanoparticle conjugates

T. Stuchinskaya, M. Moreno, M. J. Cook, D. R. Edwards and D. A. Russell, Photochem. Photobiol. Sci., 2011, 10, 822 DOI: 10.1039/C1PP05014A

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