Issue 2, 2012

Copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen

Abstract

A novel and efficient copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen has been developed under mild and neat conditions. 18O labeling experiments revealed that both oxygen atoms of the α-ketoamides derived from molecular oxygen.

Graphical abstract: Copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen

Supplementary files

Article information

Article type
Edge Article
Submitted
23 May 2011
Accepted
29 Sep 2011
First published
24 Oct 2011

Chem. Sci., 2012,3, 460-465

Copper-catalyzed direct oxidative synthesis of α-ketoamides from aryl methyl ketones, amines, and molecular oxygen

F. Du and J. Ji, Chem. Sci., 2012, 3, 460 DOI: 10.1039/C1SC00312G

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