Issue 11, 2011

Ruthenium-catalyzed intramolecular carbocyclization of alkynes with an sp3carbon involving an oxidative deprotonation process

Abstract

A novel RuCl3-catalyzed intramolecular oxidative hydration–deprotonation–cyclization method was developed for the synthesis of substituted quinolinones. The method serves as the first example of direct carbocyclization of an alkyne with an sp3carbon at the α-position of an amide through an oxidative deprotonation process.

Graphical abstract: Ruthenium-catalyzed intramolecular carbocyclization of alkynes with an sp3carbon involving an oxidative deprotonation process

Supplementary files

Article information

Article type
Edge Article
Submitted
02 Jul 2011
Accepted
20 Jul 2011
First published
05 Aug 2011

Chem. Sci., 2011,2, 2131-2134

Ruthenium-catalyzed intramolecular carbocyclization of alkynes with an sp3carbon involving an oxidative deprotonation process

B. Tang, R. Song, C. Wu, Z. Wang, Y. Liu, X. Huang, Y. Xie and J. Li, Chem. Sci., 2011, 2, 2131 DOI: 10.1039/C1SC00423A

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