Issue 1, 2012

Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

Abstract

Ruthenium-catalyzed aerobic oxidative annulations of alkynes were accomplished with co-catalytic amounts of Cu(OAc)2·H2O under ambient air. The C–H/N–H bond functionalization occurred with unparalleled selectivities and ample scope to deliver structural analogs of bioactive marine alkaloids.

Graphical abstract: Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

Supplementary files

Article information

Article type
Edge Article
Submitted
30 Aug 2011
Accepted
22 Sep 2011
First published
13 Oct 2011

Chem. Sci., 2012,3, 177-180

Ruthenium-catalyzed aerobic oxidative coupling of alkynes with 2-aryl-substituted pyrroles

L. Ackermann, L. Wang and A. V. Lygin, Chem. Sci., 2012, 3, 177 DOI: 10.1039/C1SC00619C

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