Issue 37, 2012

Metal-free TEMPO-catalyzed oxidative C–C bond formation from Csp3–H bonds using molecular oxygen as the oxidant

Abstract

An efficient TEMPO-catalyzed oxidative C–C bond formation with two Csp3–H bonds using molecular oxygen as the oxidant has been developed. The novel transformation provides a new strategy for the TEMPO–O2 catalysis to construct C–C bonds. The advantages of this method include: (1) relatively mild and neutral conditions; (2) simplicity and safety of operation; (3) a stoichiometric amount of dangerous oxidants, any transition metals, additives, even solvent, is not required.

Graphical abstract: Metal-free TEMPO-catalyzed oxidative C–C bond formation from Csp3–H bonds using molecular oxygen as the oxidant

Supplementary files

Article information

Article type
Communication
Submitted
31 Jan 2012
Accepted
15 Mar 2012
First published
16 Mar 2012

Chem. Commun., 2012,48, 4498-4500

Metal-free TEMPO-catalyzed oxidative C–C bond formation from Csp3–H bonds using molecular oxygen as the oxidant

B. Zhang, Y. Cui and N. Jiao, Chem. Commun., 2012, 48, 4498 DOI: 10.1039/C2CC30684K

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