[18F]Fluorination of an arylboronic ester using [18F]selectfluor bis(triflate): application to 6-[18F]fluoro-L-DOPA

Ida S. R. Stenhagen; Anna K. Kirjavainen; Sarita J. Forsback; Charlotte G. Jørgensen; Edward G. Robins; Sajinder K. Luthra; Olof Solin; Véronique Gouverneur

doi:10.1039/C2CC38646A

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[¹⁸F]Fluorination of an arylboronic ester using [¹⁸F]selectfluor bis(triflate): application to 6-[¹⁸F]fluoro-l-DOPA†

Ida S. R. Stenhagen,‡^a Anna K. Kirjavainen,‡^b Sarita J. Forsback,^b Charlotte G. Jørgensen,^a Edward G. Robins,^c Sajinder K. Luthra,^c Olof Solin^b and Véronique Gouverneur*^a

Author affiliations

* Corresponding authors

^a Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, UK
E-mail: veronique.gouverneur@chem.ox.ac.uk
Fax: +44 (0)1865 285002
Tel: +44 (0)1865 276544

^b Turku PET Centre, Radiopharmaceutical Chemistry Laboratory, Kiinamyllynkatu 4-8, FIN-20520 Turku, Finland

^c The Grove Centre, White Lion Road, Amersham, UK

Abstract

The Ag-mediated electrophilic [¹⁸F]fluorination of an arylboronic ester is reported. This new radiochemical transformation uses [¹⁸F]selectfluor bis(triflate) in acetone. The process gave 6-[¹⁸F]fluoro-L-DOPA with a RCY of 19 ± 12% and a specific activity of 2.6 ± 0.3 GBq μmol⁻¹.

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Article information

DOI: https://doi.org/10.1039/C2CC38646A
Article type: Communication
Submitted: 02 Dec 2012
Accepted: 02 Jan 2013
First published: 03 Jan 2013

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Chem. Commun., 2013,49, 1386-1388

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[¹⁸F]Fluorination of an arylboronic ester using [¹⁸F]selectfluor bis(triflate): application to 6-[¹⁸F]fluoro-L-DOPA

I. S. R. Stenhagen, A. K. Kirjavainen, S. J. Forsback, C. G. Jørgensen, E. G. Robins, S. K. Luthra, O. Solin and V. Gouverneur, Chem. Commun., 2013, 49, 1386 DOI: 10.1039/C2CC38646A

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