Issue 11, 2012

Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

Abstract

Powder compaction data of three polymorphic Forms I (shearing), II (bending) and III (brittle) of 6-chloro-2,4-dinitroaniline demonstrates a direct relationship among mechanical properties, crystal structure and tableting behaviour, showing the essence of structure based assessment of mechanical properties of crystals, e.g., for identifying more efficient API formulation and manufacture processes.

Graphical abstract: Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

Supplementary files

Article information

Article type
Communication
Submitted
19 Jan 2012
Accepted
13 Mar 2012
First published
15 Mar 2012

CrystEngComm, 2012,14, 3865-3867

Direct correlation among crystal structure, mechanical behaviour and tabletability in a trimorphic molecular compound

P. P. Bag, M. Chen, C. C. Sun and C. M. Reddy, CrystEngComm, 2012, 14, 3865 DOI: 10.1039/C2CE25100K

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