Issue 8, 2012

Autophagy-regulating small molecules and their therapeutic applications

Abstract

Autophagy or self-eating is a complicated cellular process that is involved in protein and organelle digestion occurring via a lysosome-dependent pathway. This process is of great importance in maintaining normal cellular homeostasis. However, disruption of autophagy is closely associated with various human diseases such as cancer, neurodegenerative disorders, heart disease and pathogen infection. Therefore, small molecules that modulate autophagy can be employed to dissect this complex process and ultimately could have high potential for the treatment of a variety of diseases. This critical review discusses general aspects of autophagy, autophagy-associated diseases and autophagy regulators for biological research and therapeutic applications (207 references).

Graphical abstract: Autophagy-regulating small molecules and their therapeutic applications

Article information

Article type
Critical Review
Submitted
01 Dec 2011
First published
31 Jan 2012

Chem. Soc. Rev., 2012,41, 3245-3263

Autophagy-regulating small molecules and their therapeutic applications

K. Baek, J. Park and I. Shin, Chem. Soc. Rev., 2012, 41, 3245 DOI: 10.1039/C2CS15328A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements