Issue 7, 2012

The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel

Abstract

The mucus layer covering the epithelial surface of the gastrointestinal tract serves as the front line of protection against the luminal contents and plays a key role in the establishment and activity of the commensal microbiota. The composition and complexity of the bacterial community within this environment is altered by the introduction of fermentable dietary components. These dietary components can change the metabolic end products of bacterial fermentation, which in turn are able to modify the expression of mucin genes and proteins leading to an increase in the mucus layer thickness. This review introduces some of the key interactions between fermentable carbohydrates, commensal bacteria, and intestinal cells which influence mucin production.

Graphical abstract: The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel

Article information

Article type
Review Article
Submitted
29 Jan 2012
Accepted
09 Apr 2012
First published
13 Apr 2012

Food Funct., 2012,3, 690-699

The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel

A. M. Barnett, N. C. Roy, W. C. McNabb and A. L. Cookson, Food Funct., 2012, 3, 690 DOI: 10.1039/C2FO30017F

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