Issue 10, 2012

Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water

Abstract

We report the first C–H hydroarylation of in situ generated ortho-quinone methides with electron-rich arenes. The reaction takes place in water without any catalyst, and is highly regioselective. Ionic and non-ionic additives provide an increase in reaction rate, yield, and regioselectivity.

Graphical abstract: Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water

Supplementary files

Article information

Article type
Communication
Submitted
24 Jan 2012
Accepted
02 Jul 2012
First published
05 Jul 2012

Green Chem., 2012,14, 2677-2681

Catalyst-free hydroarylation of in situ generated ortho-quinone methide (o-QM) with electron rich arenes in water

A. Kumar, M. Kumar and M. K. Gupta, Green Chem., 2012, 14, 2677 DOI: 10.1039/C2GC35741K

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