Issue 11, 2012

A simple and efficient approach for the palladium-catalyzed ligand-free Suzuki reaction in water

Abstract

A general and efficient protocol is described for the palladium-catalyzed ligand-free and aerobic Suzuki reaction in water in the absence of any additive. The results demonstrate that the base played a crucial role in the high efficiency. The Pd(OAc)2/(i-Pr)2NH/H2O system showed the highest catalytic activity towards the Suzuki reaction of a wide range of aryl halides bearing hydrophilic or hydrophobic groups.

Graphical abstract: A simple and efficient approach for the palladium-catalyzed ligand-free Suzuki reaction in water

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2012
Accepted
31 Aug 2012
First published
04 Sep 2012

Green Chem., 2012,14, 2999-3003

A simple and efficient approach for the palladium-catalyzed ligand-free Suzuki reaction in water

C. Liu, Y. Zhang, N. Liu and J. Qiu, Green Chem., 2012, 14, 2999 DOI: 10.1039/C2GC36098E

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