Issue 6, 2012
From the journal:

MedChemComm

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes†

Chung-Hang Leung,*ab   Hui Yang,c   Victor Pui-Yan Ma,c   Daniel Shiu-Hin Chan,c   Hai-Jing Zhong,ab   Ying-Wei Li,d   Wang-Fun Fongd  and  Dik-Lung Ma*c  

* Corresponding authors

a Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China
E-mail: DuncanLeung@umac.mo

b State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China

c Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
E-mail: edmondma@hkbu.edu.hk

d Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China

Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Graphical abstract: Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2MD00306F
Article type
Concise Article
Submitted
14 Dec 2011
Accepted
07 Apr 2012
First published
16 Apr 2012

Med. Chem. Commun., 2012,3, 696-698

Permissions

Request permissions

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

C. Leung, H. Yang, V. P. Ma, D. S. Chan, H. Zhong, Y. Li, W. Fong and D. Ma, Med. Chem. Commun., 2012, 3, 696 DOI: 10.1039/C2MD00306F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements